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12.13.2009

H1N1 Influenza A - Swine Flu: 13 December Brief Update

10,000 H1N1 Swine Flu Deaths: "... 'Sadly, there were nearly 10,000 deaths: 1,100 in children and 7,500 among young adults,' CDC Director Thomas R. Frieden, MD, MPH, said at a news conference. 'That is much higher than we would see in a usual flu season. This is a flu that is much harder on young people and that has largely spared the elderly.'

The new estimates suggest that about 15% of the population -- one in six Americans -- has had the H1N1 swine flu..."

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CDC sharply raises H1N1 case estimates; kids hit hard: "Another month's worth of data on H1N1 influenza has led federal officials to more than double their estimates of total cases, hospitalizations, and deaths and to assert that the impact on children and younger adults has been far greater than that of a typical flu season..."
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Nearly 10,000 U.S. deaths caused by swine flu - Swine flu- msnbc.com: "... Flu estimates are also difficult to compare. Seasonal flu kills about 36,000 Americans each year, according to a long-standing estimate. But that number includes many elderly people who had not only seasonal flu and related pneumonia but also heart attacks and strokes. The new CDC swine flu estimates do not include heart attacks and strokes, mainly because there hasn't been time to collect that kind of data.

So it's likely the new estimate is conservative, and undercounts elderly deaths, CDC officials acknowledged.

Even so, the number of hospitalizations and deaths of younger people from swine flu far exceed what normally occurs in the same ages from the winter flu.

'This flu is much harder on younger people,' Frieden said...

... there are still plenty of ill people — as many as during the worst days of many regular flu seasons. And CDC officials have said the signs of declining cases do not necessarily mean the worst is over...

... Also on Thursday, the CDC released a study that found American Indians and Alaska Natives have died from swine flu at a rate four times greater than other Americans..."

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D225G and D225N In Utah Patient Raises Pandemic Concerns: "Recombinomics Commentary 23:55
December 6, 2009
The CDC has put HA sequences, A/Utah/42/2009, from a Utah patient (28F) on deposit at GISAID, which has D225G and D225N. Moreover, the sequence from the original sample gives mixed signals at tandem positions, revealing significant heterogeneity that the codon. A clone for the original sample has D225G. D225N and D225G have been identified in necropsy lung samples from Brazil (A Sao Paulo/53845/2009 and A/Sao Paulo/53838/2009 have D225N while A/Sao Paulo/53225/2009 and A/Sao Paulo/53206/2009 have D225G) raising concerns that these polymorphisms are associated with more severe disease..."
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Corporate employers got scarce flu vaccine - USATODAY.com: "When the swine flu vaccine was most scarce, health officials gave thousands of doses to corporate clinics at Walt Disney World, Toyota, defense contractors, oil companies and cruise lines, according to a USA TODAY review of vaccine distribution data from three states.

USA TODAY examined how state health departments distributed H1N1 vaccine after public outcry last month over Wall Street firms such as Goldman Sachs receiving doses while doctors and hospitals encountered shortages. The data show other companies got the vaccine in October and early November. In some cases, early doses went to people not deemed most at risk by the Centers for Disease Control and Prevention..."

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Fatal Tamiflu Resistant H1N1 Cases In the Netherlands: "Recombinomics Commentary 13:55
December 8, 2009

... data extend numbers released last week which indicated a Tamiflu resistance tipping point had been crossed. In the past three weeks the rate of reported H274Y cases in the US increased almost 10 fold, and human to human transmission had been reported at Duke University hospital as well as a hospital in Wales. Other geographic clusters had been reported in the Washington, DC area as well as eastern Pennsylvania in the US, and Edinburgh in Scotland. This explosion in Tamiflu/Peramivir resistance led to concerns of H274Y pairing up with receptor binding domain changes at position 225..."


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